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Case Studies
case study
Singapore – HTA Value Dossier Localisation & Economic Model Adaptation for CAR-T Therapy

  • Objective

    Develop Singapore-specific HTA submission materials by localizing the Global Value Dossier and adapting the Budget Impact Model (BIM) and Cost-Effectiveness Analysis (CEA) models to meet Agency for Care Effectiveness (ACE) requirements for CAR-T therapy reimbursement evaluation.

  • Approach

    Reviewed global evidence and Singapore ACE submission requirements, localized the value dossier using country-specific clinical and epidemiological data, conducted systematic literature reviews, incorporated local healthcare resource utilization & cost inputs, and adapted BIM and CEA models with supporting technical reports.

  • Deliverables

    Comprehensive Singapore HTA submission package including localized Global Value Dossiers for DLBCL and FL indications, adapted Budget Impact and Cost-Effectiveness models, BIM and CEA technical reports, local evidence synthesis, and country-specific economic analyses ready for ACE submission.

  • Outcome

    Successfully delivered a complete Singapore-specific evidence package supporting HTA submission, providing robust clinical and economic evidence through localized dossiers and validated health economic models to facilitate reimbursement evaluation and market access decision-making.